Developing a diagnostic tool for Motor Neurone Disease using protein metabolism

Institution

The Florey

Illness/Condition

Motor Neuron Disease

Year Of Grant

2022

Researcher

A/Professor Bradley Turner
Dr Chiu Mun Sarah Lee
Dr Dedreia Tull
Dr Nirma Perera

Summary

In a significant leap forward for neurodegenerative disease research, a team of scientists, led by researchers at the Florey Institute in Melbourne, has achieved a major milestone in understanding and potentially treating conditions such as Alzheimer’s disease and motor neuron disease (MND). The study focused on developing a groundbreaking “autophagometer” — a minimally invasive tool capable of measuring autophagy activity in living animals. Autophagy, a crucial process for brain function, is disrupted in neurodegenerative diseases, leading to the accumulation of toxic protein deposits in nerve cells, contributing to nerve cell death in these conditions.