Personalising pain relief- the right opioid for the right person at the right time
The way cancer pain is managed in palliative care has not changed significantly for many decades. This project has helped progress knowledge on the use of opioids in cancer pain, through the interrogation of a novel longitudinal study looking at the possibility of how genes interact with how people respond to opioids at a cellular […]
Understanding the mechanisms of Multiple Sclerosis disease flares
The team were able to show that P2X7R is expressed in peripheral monocytes of MS patients and that its channel function is intact. Importantly the channel response was more pronounced in MS patients versus healthy control monocytes. Steroids are generally used to treat MS relapse and their mechanism of action is not entirely clear. We […]
